Dopamine Receptor D5 Signaling Plays a Dual Role in Experimental Autoimmune Encephalomyelitis Potentiating Th17-Mediated Immunity and Favoring Suppressive Activity of Regulatory T-Cells

Dopamine Receptor D5 Signaling Plays a Dual Role in Experimental Autoimmune Encephalomyelitis Potentiating Th17-Mediated Immunity and Favoring Suppressive Activity of Regulatory T-Cells

A number of studies have shown pharmacologic evidence indicating that stimulation of type I dopamine receptor (DR), favors T-helper-17 (Th17)-mediated immunity involved in experimental autoimmune encephalomyelitis (EAE) and in some other inflammatory disorders. Nevertheless, the lack of drugs that m...

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Bibliographic Details
Main Authors: Francisco Osorio-Barrios, Carolina Prado, Francisco Contreras, Rodrigo Pacheco
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Th17 response
T-cell activation
regulatory T-cells
dopamine
knockout mice
experimental autoimmune encephalomyelitis
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00192/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00192/full

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