The role of Pitx2 and Pitx3 in muscle stem cells gives new insights into P38α MAP kinase and redox regulation of muscle regeneration

The role of Pitx2 and Pitx3 in muscle stem cells gives new insights into P38α MAP kinase and redox regulation of muscle regeneration

Skeletal muscle regeneration depends on satellite cells. After injury these muscle stem cells exit quiescence, proliferate and differentiate to regenerate damaged fibres. We show that this progression is accompanied by metabolic changes leading to increased production of reactive oxygen species (ROS...

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Bibliographic Details
Main Authors: Aurore L'honoré, Pierre-Henri Commère, Elisa Negroni, Giorgia Pallafacchina, Bertrand Friguet, Jacques Drouin, Margaret Buckingham, Didier Montarras
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-08-01
Series:eLife
Subjects:
muscle stem cell
redox state
regeneration
Pitx2/3
cell therapy
p38α MAPK
Online Access:https://elifesciences.org/articles/32991

Internet

https://elifesciences.org/articles/32991

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