Quantification of mutant SPOP proteins in prostate cancer using mass spectrometry-based targeted proteomics

Quantification of mutant SPOP proteins in prostate cancer using mass spectrometry-based targeted proteomics

Abstract Background Speckle-type POZ protein (SPOP) is an E3 ubiquitin ligase adaptor protein that functions as a potential tumor suppressor, and SPOP mutations have been identified in ~10% of human prostate cancers. However, it remains unclear if mutant SPOP proteins can be utilized as biomarkers f...

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Bibliographic Details
Main Authors: Hui Wang, Christopher E. Barbieri, Jintang He, Yuqian Gao, Tujin Shi, Chaochao Wu, Athena A. Schepmoes, Thomas L. Fillmore, Sung-Suk Chae, Dennis Huang, Juan Miguel Mosquera, Wei-Jun Qian, Richard D. Smith, Sudhir Srivastava, Jacob Kagan, David G. Camp, Karin D. Rodland, Mark A. Rubin, Tao Liu
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Journal of Translational Medicine
Subjects:
Mass spectrometry
Targeted proteomics
SPOP mutation
Prostate cancer
Biomarker
PRISM-SRM
Online Access:http://link.springer.com/article/10.1186/s12967-017-1276-7

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http://link.springer.com/article/10.1186/s12967-017-1276-7

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