Major and minor group rhinoviruses elicit differential signaling and cytokine responses as a function of receptor-mediated signal transduction.

Major and minor group rhinoviruses elicit differential signaling and cytokine responses as a function of receptor-mediated signal transduction.

Major- and minor-group human rhinoviruses (HRV) enter their host by binding to the cell surface molecules ICAM-1 and LDL-R, respectively, which are present on both macrophages and epithelial cells. Although epithelial cells are the primary site of productive HRV infection, previous studies have impl...

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Bibliographic Details
Main Authors: Bryce A Schuler, Michael T Schreiber, Luyuan Li, Michal Mokry, Megan L Kingdon, Dana N Raugi, Cosonya Smith, Chelsea Hameister, Vincent R Racaniello, David J Hall
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3988043?pdf=render

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http://europepmc.org/articles/PMC3988043?pdf=render

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