Betaine Attenuates Osteoarthritis by Inhibiting Osteoclastogenesis and Angiogenesis in Subchondral Bone

Betaine Attenuates Osteoarthritis by Inhibiting Osteoclastogenesis and Angiogenesis in Subchondral Bone

Osteoarthritis (OA) is the most common type of arthritis with no effective therapy. Subchondral bone and overlying articular cartilage are closely associated and function as “osteo-chondral unit” in the joint. Abnormal mechanical load leads to activated osteoclast activity and increased bone resorpt...

Full description

Bibliographic Details
Main Authors: Wang Yajun, Cui Jin, Gu Zhengrong, Fang Chao, Hu Yan, Weng Weizong, Li Xiaoqun, Zhou Qirong, Chen Huiwen, Zhang Hao, Guo Jiawei, Zhuang Xinchen, Sheng Shihao, Wang Sicheng, Chen Xiao, Su Jiacan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
betaine
osteoclastogenesis
subchondral bone
angiogenesis
osteoarthritis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.723988/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.723988/full

Similar Items