Antamanide, a derivative of Amanita phalloides, is a novel inhibitor of the mitochondrial permeability transition pore.

Antamanide, a derivative of Amanita phalloides, is a novel inhibitor of the mitochondrial permeability transition pore.

Antamanide is a cyclic decapeptide derived from the fungus Amanita phalloides. Here we show that antamanide inhibits the mitochondrial permeability transition pore, a central effector of cell death induction, by targeting the pore regulator cyclophilin D. Indeed, (i) permeability transition pore inh...

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Bibliographic Details
Main Authors: Luca Azzolin, Nicola Antolini, Andrea Calderan, Paolo Ruzza, Marco Sciacovelli, Oriano Marin, Stefano Mammi, Paolo Bernardi, Andrea Rasola
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3030572?pdf=render

Internet

http://europepmc.org/articles/PMC3030572?pdf=render

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