Antamanide, a derivative of Amanita phalloides, is a novel inhibitor of the mitochondrial permeability transition pore.
Antamanide is a cyclic decapeptide derived from the fungus Amanita phalloides. Here we show that antamanide inhibits the mitochondrial permeability transition pore, a central effector of cell death induction, by targeting the pore regulator cyclophilin D. Indeed, (i) permeability transition pore inh...
Main Authors: | Luca Azzolin, Nicola Antolini, Andrea Calderan, Paolo Ruzza, Marco Sciacovelli, Oriano Marin, Stefano Mammi, Paolo Bernardi, Andrea Rasola |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3030572?pdf=render |
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