Gene expression profile and cancer-associated pathways linked to progesterone receptor isoform a (PRA) predominance in transgenic mouse mammary glands

Gene expression profile and cancer-associated pathways linked to progesterone receptor isoform a (PRA) predominance in transgenic mouse mammary glands

Abstract Background Progesterone receptor (PR) is expressed from a single gene as two isoforms, PRA and PRB. In normal breast human tissue, PRA and PRB are expressed in equimolar ratios, but isoform ratio is altered during malignant progression, usually leading to high PRA:PRB ratios. We took advant...

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Bibliographic Details
Main Authors: María José Carlini, María Sol Recouvreux, Marina Simian, Maria Aparecida Nagai
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Cancer
Subjects:
Progesterone receptor
Isoforms
Transgenic mice
Mammary gland
Hyperplasia
Breast cancer
Online Access:http://link.springer.com/article/10.1186/s12885-018-4550-z

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http://link.springer.com/article/10.1186/s12885-018-4550-z

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