Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation

Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation

The instability of DNA nanostructures in physiological environments has hampered their use as therapeutics and diagnostic agents inin vivoapplications. Here, the authors show that coating DNA origami with oligolysine-PEG moieties improves their pharmacokinetic properties in mouse models.

Bibliographic Details
Main Authors: Nandhini Ponnuswamy, Maartje M. C. Bastings, Bhavik Nathwani, Ju Hee Ryu, Leo Y. T. Chou, Mathias Vinther, Weiwei Aileen Li, Frances M. Anastassacos, David J. Mooney, William M. Shih
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15654

Internet

https://doi.org/10.1038/ncomms15654

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