Characterization of TTN Novex Splicing Variants across Species and the Role of RBM20 in Novex-Specific Exon Splicing

Characterization of TTN Novex Splicing Variants across Species and the Role of RBM20 in Novex-Specific Exon Splicing

Titin (TTN) is a major disease-causing gene in cardiac muscle. Titin (TTN) contains 363 exons in human encoding various sizes of TTN protein due to alternative splicing regulated mainly by RNA binding motif 20 (RBM20). Three isoforms of TTN protein are produced by mutually exclusive exons 45 (Novex...

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Bibliographic Details
Main Authors: Zhilong Chen, Jiangping Song, Liang Chen, Chaoqun Zhu, Hanfang Cai, Mingming Sun, Allysa Stern, Paul Mozdziak, Ying Ge, Warrie J. Means, Wei Guo
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Genes
Subjects:
TTN
RBM20
Novex isoforms
cardiomyopathy
alternative splicing
Online Access:http://www.mdpi.com/2073-4425/9/2/86

Internet

http://www.mdpi.com/2073-4425/9/2/86

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