Feedback activation of AMPK-mediated autophagy acceleration is a key resistance mechanism against SCD1 inhibitor-induced cell growth inhibition.

Feedback activation of AMPK-mediated autophagy acceleration is a key resistance mechanism against SCD1 inhibitor-induced cell growth inhibition.

Elucidating the bioactive compound modes of action is crucial for increasing success rates in drug development. For anticancer drugs, defining effective drug combinations that overcome resistance improves therapeutic efficacy. Herein, by using a biologically annotated compound library, we performed...

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Bibliographic Details
Main Authors: Akito Ono, Osamu Sano, Ken-Ichi Kazetani, Takamichi Muraki, Keisuke Imamura, Hiroyuki Sumi, Junji Matsui, Hidehisa Iwata
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5509324?pdf=render

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http://europepmc.org/articles/PMC5509324?pdf=render

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