Bazedoxifene as a novel GP130 inhibitor for Colon Cancer therapy

Bazedoxifene as a novel GP130 inhibitor for Colon Cancer therapy

Abstract Background Interleukin-11 (IL-11), a dominant IL-6 family cytokine, is involved in tumorigenesis, tumor progression and differentiation in colon cancer cells. IL-11 signaling has been recently identified as a potential therapeutic target in colon cancer. Bazedoxifene, a third- generation se...

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Bibliographic Details
Main Authors: Jia Wei, Ling Ma, Yi-Hui Lai, Ruijie Zhang, Huameng Li, Chenglong Li, Jiayuh Lin
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Colon cancer
Bazedoxifene
Oxaliplatin
GP130
IL-11
STAT3
Online Access:http://link.springer.com/article/10.1186/s13046-019-1072-8

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http://link.springer.com/article/10.1186/s13046-019-1072-8

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