The Arabidopsis thaliana Poly(ADP-Ribose) Polymerases 1 and 2 Modify DNA by ADP-Ribosylating Terminal Phosphate Residues

The Arabidopsis thaliana Poly(ADP-Ribose) Polymerases 1 and 2 Modify DNA by ADP-Ribosylating Terminal Phosphate Residues

Proteins from the poly(ADP-ribose) polymerase (PARP) family, such as PARP1 and PARP2, use NAD+ as a substrate to catalyze the synthesis of polymeric chains consisting of ADP-ribose units covalently attached to an acceptor molecule. PARP1 and PARP2 are viewed as DNA damage sensors that, upon binding...

Full description

Bibliographic Details
Main Authors: Sabira Taipakova, Aigerim Kuanbay, Christine Saint-Pierre, Didier Gasparutto, Yeldar Baiken, Regina Groisman, Alexander A. Ishchenko, Murat Saparbaev, Amangeldy K. Bissenbaev
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
plant DNA repair
Arabidopsis thaliana
DNA strand break
nicotinamide adenine dinucleotide (NAD+)
poly(ADP-ribose) polymerase (PARP)
ADP-ribosylation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.606596/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.606596/full

Similar Items