An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors
N-methyl D-aspartate receptor (NMDAR) activity is modulated by Src tyrosine kinase via the mitochondrial protein NADH dehydrogenase subunit 2 (ND2). Here the authors show that ND2 interacts with the transmembrane region of NMDAR GluN1 subunit, a process that is crucial for Src regulation of NMDAR ac...
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2017-05-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms15220 |
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doaj-50c00c45052a4a68a4e123d4c54090df2021-05-11T07:29:57ZengNature Publishing GroupNature Communications2041-17232017-05-018111410.1038/ncomms15220An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptorsDavid P. Scanlon0Alaji Bah1Mickaël Krzeminski2Wenbo Zhang3Heather L. Leduc-Pessah4Yi Na Dong5Julie D. Forman-Kay6Michael W. Salter7Program in Neurosciences & Mental Health, The Hospital for Sick ChildrenProgram in Molecular Medicine, The Hospital for Sick ChildrenProgram in Molecular Medicine, The Hospital for Sick ChildrenProgram in Neurosciences & Mental Health, The Hospital for Sick ChildrenProgram in Neurosciences & Mental Health, The Hospital for Sick ChildrenProgram in Neurosciences & Mental Health, The Hospital for Sick ChildrenProgram in Molecular Medicine, The Hospital for Sick ChildrenProgram in Neurosciences & Mental Health, The Hospital for Sick ChildrenN-methyl D-aspartate receptor (NMDAR) activity is modulated by Src tyrosine kinase via the mitochondrial protein NADH dehydrogenase subunit 2 (ND2). Here the authors show that ND2 interacts with the transmembrane region of NMDAR GluN1 subunit, a process that is crucial for Src regulation of NMDAR activity.https://doi.org/10.1038/ncomms15220 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
David P. Scanlon Alaji Bah Mickaël Krzeminski Wenbo Zhang Heather L. Leduc-Pessah Yi Na Dong Julie D. Forman-Kay Michael W. Salter |
spellingShingle |
David P. Scanlon Alaji Bah Mickaël Krzeminski Wenbo Zhang Heather L. Leduc-Pessah Yi Na Dong Julie D. Forman-Kay Michael W. Salter An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors Nature Communications |
author_facet |
David P. Scanlon Alaji Bah Mickaël Krzeminski Wenbo Zhang Heather L. Leduc-Pessah Yi Na Dong Julie D. Forman-Kay Michael W. Salter |
author_sort |
David P. Scanlon |
title |
An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors |
title_short |
An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors |
title_full |
An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors |
title_fullStr |
An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors |
title_full_unstemmed |
An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors |
title_sort |
evolutionary switch in nd2 enables src kinase regulation of nmda receptors |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2017-05-01 |
description |
N-methyl D-aspartate receptor (NMDAR) activity is modulated by Src tyrosine kinase via the mitochondrial protein NADH dehydrogenase subunit 2 (ND2). Here the authors show that ND2 interacts with the transmembrane region of NMDAR GluN1 subunit, a process that is crucial for Src regulation of NMDAR activity. |
url |
https://doi.org/10.1038/ncomms15220 |
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