An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors

An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors

N-methyl D-aspartate receptor (NMDAR) activity is modulated by Src tyrosine kinase via the mitochondrial protein NADH dehydrogenase subunit 2 (ND2). Here the authors show that ND2 interacts with the transmembrane region of NMDAR GluN1 subunit, a process that is crucial for Src regulation of NMDAR ac...

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Main Authors: David P. Scanlon, Alaji Bah, Mickaël Krzeminski, Wenbo Zhang, Heather L. Leduc-Pessah, Yi Na Dong, Julie D. Forman-Kay, Michael W. Salter
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15220
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spelling doaj-50c00c45052a4a68a4e123d4c54090df2021-05-11T07:29:57ZengNature Publishing GroupNature Communications2041-17232017-05-018111410.1038/ncomms15220An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptorsDavid P. Scanlon0Alaji Bah1Mickaël Krzeminski2Wenbo Zhang3Heather L. Leduc-Pessah4Yi Na Dong5Julie D. Forman-Kay6Michael W. Salter7Program in Neurosciences & Mental Health, The Hospital for Sick ChildrenProgram in Molecular Medicine, The Hospital for Sick ChildrenProgram in Molecular Medicine, The Hospital for Sick ChildrenProgram in Neurosciences & Mental Health, The Hospital for Sick ChildrenProgram in Neurosciences & Mental Health, The Hospital for Sick ChildrenProgram in Neurosciences & Mental Health, The Hospital for Sick ChildrenProgram in Molecular Medicine, The Hospital for Sick ChildrenProgram in Neurosciences & Mental Health, The Hospital for Sick ChildrenN-methyl D-aspartate receptor (NMDAR) activity is modulated by Src tyrosine kinase via the mitochondrial protein NADH dehydrogenase subunit 2 (ND2). Here the authors show that ND2 interacts with the transmembrane region of NMDAR GluN1 subunit, a process that is crucial for Src regulation of NMDAR activity.https://doi.org/10.1038/ncomms15220
collection DOAJ
language English
format Article
sources DOAJ
author David P. Scanlon
Alaji Bah
Mickaël Krzeminski
Wenbo Zhang
Heather L. Leduc-Pessah
Yi Na Dong
Julie D. Forman-Kay
Michael W. Salter
spellingShingle David P. Scanlon
Alaji Bah
Mickaël Krzeminski
Wenbo Zhang
Heather L. Leduc-Pessah
Yi Na Dong
Julie D. Forman-Kay
Michael W. Salter
An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors
Nature Communications
author_facet David P. Scanlon
Alaji Bah
Mickaël Krzeminski
Wenbo Zhang
Heather L. Leduc-Pessah
Yi Na Dong
Julie D. Forman-Kay
Michael W. Salter
author_sort David P. Scanlon
title An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors
title_short An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors
title_full An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors
title_fullStr An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors
title_full_unstemmed An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors
title_sort evolutionary switch in nd2 enables src kinase regulation of nmda receptors
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-05-01
description N-methyl D-aspartate receptor (NMDAR) activity is modulated by Src tyrosine kinase via the mitochondrial protein NADH dehydrogenase subunit 2 (ND2). Here the authors show that ND2 interacts with the transmembrane region of NMDAR GluN1 subunit, a process that is crucial for Src regulation of NMDAR activity.
url https://doi.org/10.1038/ncomms15220
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