Mastering the canonical loop of serine protease inhibitors: enhancing potency by optimising the internal hydrogen bond network.

Mastering the canonical loop of serine protease inhibitors: enhancing potency by optimising the internal hydrogen bond network.

BACKGROUND: Canonical serine protease inhibitors commonly bind to their targets through a rigid loop stabilised by an internal hydrogen bond network and disulfide bond(s). The smallest of these is sunflower trypsin inhibitor (SFTI-1), a potent and broad-range protease inhibitor. Recently, we re-engi...

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Bibliographic Details
Main Authors: Joakim E Swedberg, Simon J de Veer, Kei C Sit, Cyril F Reboul, Ashley M Buckle, Jonathan M Harris
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3083445?pdf=render

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http://europepmc.org/articles/PMC3083445?pdf=render

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