7-Acetylsinumaximol B Induces Apoptosis and Autophagy in Human Gastric Carcinoma Cells through Mitochondria Dysfunction and Activation of the PERK/eIF2α/ATF4/CHOP Signaling Pathway

7-Acetylsinumaximol B Induces Apoptosis and Autophagy in Human Gastric Carcinoma Cells through Mitochondria Dysfunction and Activation of the PERK/eIF2α/ATF4/CHOP Signaling Pathway

The 7-Acetylsinumaximol B (7-AB), a bioactive cembranoid, was originally discovered from aquaculture soft coral Sinularia sandensis. The current study investigated the anti-proliferative property of 7-AB towards the NCI-N87 human gastric cancer cell line. An MTT cell proliferative assay was applied...

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Bibliographic Details
Main Authors: Tsung-Chang Tsai, Kuei-Hung Lai, Jui-Hsin Su, Yu-Jen Wu, Jyh-Horng Sheu
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Marine Drugs
Subjects:
7-acetylsinumaximol B
human gastric cancer cells
endoplasmic reticulum stress
mitochondrial inactivation
autophagy
Online Access:http://www.mdpi.com/1660-3397/16/4/104

Internet

http://www.mdpi.com/1660-3397/16/4/104

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