The fibrin Bβ125-135 site is involved in the lateral association of protofibrils

The fibrin Bβ125-135 site is involved in the lateral association of protofibrils

Earlier we reported that during the human fibrinogen to fibrin transition a neoantigenic determinant was exposed in the Bβ119-133 fragment, where a hinge locus is situated. The fibrin-specific mAb FnI-3c and its Fab-fragment with epitope in this fragment inhibited the lateral association of protofib...

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Bibliographic Details
Main Authors: E. Lugovskoi, N. Pydiura, Y. Makogonenko, L. Urvant, P. Gritsenko, I. Kolesnikova, N. Lugovska, S. Komisarenko
Format: Article
Language:English
Published: National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine. 2020-06-01
Series:Ukrainian Biochemical Journal
Subjects:
coiled-coil connector
fibrinogen to fibrin transition
hinge region
neoantigenic determinant
protofibril lateral association
Online Access:http://ukrbiochemjournal.org/wp-content/uploads/2020/08/Lugovskoi_3_20.pdf

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http://ukrbiochemjournal.org/wp-content/uploads/2020/08/Lugovskoi_3_20.pdf

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