Endogenous synthesis of n-3 polyunsaturated fatty acids in fat-1 transgenic mice ameliorates streptozocin-induced diabetic nephropathy

Endogenous synthesis of n-3 polyunsaturated fatty acids in fat-1 transgenic mice ameliorates streptozocin-induced diabetic nephropathy

Although n-3 polyunsaturated fatty acids (PUFAs) exhibit biological activity in many inflammatory diseases, their renoprotective effects against diabetic nephropathy (DN) have been controversial. Here, fat-1 transgenic mice were used to investigate the effects of n-3 PUFAs on streptozocin (STZ)-indu...

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Bibliographic Details
Main Authors: Yuan-Ming Zhang, Xiao-Hong Zhang, Pan Zhu, Rong-Hui Tan, Jin-Shun Zhao, Feng Wang, Jin-Jie Zhang, Wang Yan, Yang Xi, Jian-Bo Wan, Jing-Xuan Kang, Zu-Quan Zou, Shi-Zhong Bu
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Journal of Functional Foods
Subjects:
Fat-1
n-3 PUFAs
NLRP3 inflammasome
Lipid mediators
E-cadherin
Diabetic nephropathy
Online Access:http://www.sciencedirect.com/science/article/pii/S175646461830149X

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http://www.sciencedirect.com/science/article/pii/S175646461830149X

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