Promotion of Survival and Engraftment of Transplanted Adipose Tissue-Derived Stromal and Vascular Cells by Overexpression of Manganese Superoxide Dismutase

Promotion of Survival and Engraftment of Transplanted Adipose Tissue-Derived Stromal and Vascular Cells by Overexpression of Manganese Superoxide Dismutase

Short-term persistence of transplanted cells during early post-implant period limits clinical efficacy of cell therapy. Poor cell survival is mainly due to the harsh hypoxic microenvironment transplanted cells face at the site of implantation and to anoikis, driven by cell adhesion loss. We evaluate...

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Bibliographic Details
Main Authors: Silvia Baldari, Giuliana Di Rocco, Angelo Trivisonno, Daniela Samengo, Giovambattista Pani, Gabriele Toietta
Format: Article
Language:English
Published: MDPI AG 2016-07-01
Series:International Journal of Molecular Sciences
Subjects:
adipose tissue-derived stromal and vascular cells
bioluminescence imaging
cell therapy
cell survival
cell transplantation
hypoxia
manganese superoxide dismutase
oxidative stress
reactive oxygen species
Online Access:http://www.mdpi.com/1422-0067/17/7/1082

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http://www.mdpi.com/1422-0067/17/7/1082

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