Pyridine-Containing Macrocycles Display MMP-2/9 Inhibitory Activity and Distinct Effects on Migration and Invasion of 2D and 3D Breast Cancer Models

Pyridine-Containing Macrocycles Display MMP-2/9 Inhibitory Activity and Distinct Effects on Migration and Invasion of 2D and 3D Breast Cancer Models

The role of metalloproteinases (MMPs) on the migration and invasion of cancer cells has been correlated with tumor aggressiveness, namely with the up-regulation of MMP-2 and 9. Herein, two pyridine-containing macrocyclic compounds, [15]pyN<sub>5</sub> and [16]pyN<sub>5</sub>,...

Full description

Bibliographic Details
Main Authors: Susana Proença, Bernardo Antunes, Rita C. Guedes, Filipa Ramilo-Gomes, M. Fátima Cabral, Judite Costa, Ana S. Fernandes, Matilde Castro, Nuno G. Oliveira, Joana P. Miranda
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
pyridine-containing macrocyclic
molecular docking studies
3d models
breast cancer
mmp inhibitors
migration and invasion
Online Access:https://www.mdpi.com/1422-0067/20/20/5109

Internet

https://www.mdpi.com/1422-0067/20/20/5109

Similar Items