AKT inhibitors promote cell death in cervical cancer through disruption of mTOR signaling and glucose uptake.

AKT inhibitors promote cell death in cervical cancer through disruption of mTOR signaling and glucose uptake.

PI3K/AKT pathway alterations are associated with incomplete response to chemoradiation in human cervical cancer. This study was performed to test for mutations in the PI3K pathway and to evaluate the effects of AKT inhibitors on glucose uptake and cell viability.Mutational analysis of DNA from 140 p...

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Bibliographic Details
Main Authors: Ramachandran Rashmi, Carl DeSelm, Cynthia Helms, Anne Bowcock, Buck E Rogers, Janet L Rader, Perry W Grigsby, Julie K Schwarz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3976291?pdf=render

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http://europepmc.org/articles/PMC3976291?pdf=render

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