Chemo-Enzymatic Synthesis of Silybin and 2,3-Dehydrosilybin Dimers

Chemo-Enzymatic Synthesis of Silybin and 2,3-Dehydrosilybin Dimers

Divalent or multivalent molecules often show enhanced biological activity relative to the simple monomeric units. Here we present enzymatically and chemically prepared dimers of the flavonolignans silybin and 2,3-dehydrosilybin. Their electrochemical behavior was studied by in situ and ex situ squar...

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Bibliographic Details
Main Authors: Eva Vavříková, Jan Vacek, Kateřina Valentová, Petr Marhol, Jitka Ulrichová, Marek Kuzma, Vladimír Křen
Format: Article
Language:English
Published: MDPI AG 2014-04-01
Series:Molecules
Subjects:
flavonolignan
silybin
silibinin
dimerization
electrochemistry
antioxidant
microsomal lipid peroxidation
HUVEC
cytotoxicity
Online Access:http://www.mdpi.com/1420-3049/19/4/4115

Internet

http://www.mdpi.com/1420-3049/19/4/4115

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