Polygalae Radix Extract Prevents Axonal Degeneration and Memory Deficits in a Transgenic Mouse Model of Alzheimer’s Disease

Polygalae Radix Extract Prevents Axonal Degeneration and Memory Deficits in a Transgenic Mouse Model of Alzheimer’s Disease

Memory impairments in Alzheimer’s disease (AD) occur due to degenerated axons and disrupted neural networks. Since only limited recovery is possible after the destruction of neural networks, preventing axonal degeneration during the early stages of disease progression is necessary to prevent AD. Pol...

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Bibliographic Details
Main Authors: Tomoharu Kuboyama, Keisuke Hirotsu, Tetsuya Arai, Hiroo Yamasaki, Chihiro Tohda
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Pharmacology
Subjects:
Alzheimer’s disease
Polygalae Radix
axon degeneration
amyloid β
endocytosis
growth cone collapse
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00805/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00805/full

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