Lactoferrin Retargets Human Adenoviruses to TLR4 to Induce an Abortive NLRP3-Associated Pyroptotic Response in Human Phagocytes

Lactoferrin Retargets Human Adenoviruses to TLR4 to Induce an Abortive NLRP3-Associated Pyroptotic Response in Human Phagocytes

Despite decades of clinical and preclinical investigations, we still poorly grasp our innate immune response to human adenoviruses (HAdVs) and their vectors. In this study, we explored the impact of lactoferrin on three HAdV types that are being used as vectors for vaccines. Lactoferrin is a secrete...

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Bibliographic Details
Main Authors: Coraline Chéneau, Karsten Eichholz, Tuan Hiep Tran, Thi Thu Phuong Tran, Océane Paris, Corinne Henriquet, Jeffrey J. Bajramovic, Martine Pugniere, Eric J. Kremer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
Lactoferrin
adenovirus
dendritic cell (DC)
TLR4 (Toll-like receptor 4)
IL-1β
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.685218/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.685218/full

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