SphK1/S1P Mediates PDGF-Induced Pulmonary Arterial Smooth Muscle Cell Proliferation via miR-21/BMPRII/Id1 Signaling Pathway

SphK1/S1P Mediates PDGF-Induced Pulmonary Arterial Smooth Muscle Cell Proliferation via miR-21/BMPRII/Id1 Signaling Pathway

Background/Aims: The underlying molecular mechanisms involved in sphingosine kinase 1 (SphK1)/sphingosine 1-phosphate (S1P) mediation of platelet-derived growth factor (PDGF)-induced pulmonary arterial smooth muscle cell (PASMC) proliferation are still unclear, and the present study aims to address...

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Bibliographic Details
Main Authors: Fangwei Li, Jian Wang, Yanting Zhu, Lu Liu, Wei Feng, Wenhua Shi, Qingting Wang, Qianqian Zhang, Limin Chai, Manxiang Li
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
SphK1
S1P
PDGF
Pulmonary Arterial Smooth Muscle Cell
Proliferation
miR-21
BMPRII
Id1
Online Access:https://www.karger.com/Article/FullText/495243

Internet

https://www.karger.com/Article/FullText/495243

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