Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly

Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly

Centrioles organise centrosomes and template cilia and flagella. Several centriole and centrosome proteins have been linked to microcephaly (MCPH), a neuro-developmental disease associated with small brain size. CPAP (MCPH6) and STIL (MCPH7) are required for centriole assembly, but it is unclear how...

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Bibliographic Details
Main Authors: Matthew A Cottee, Nadine Muschalik, Yao Liang Wong, Christopher M Johnson, Steven Johnson, Antonina Andreeva, Karen Oegema, Susan M Lea, Jordan W Raff, Mark van Breugel
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-09-01
Series:eLife
Subjects:
centriole
centrosome
CPAP
microcephaly
STIL
Online Access:https://elifesciences.org/articles/01071

Internet

https://elifesciences.org/articles/01071

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