Chondral Differentiation of Induced Pluripotent Stem Cells Without Progression Into the Endochondral Pathway

Chondral Differentiation of Induced Pluripotent Stem Cells Without Progression Into the Endochondral Pathway

A major problem with chondrocytes derived in vitro from stem cells is undesired hypertrophic degeneration, to which articular chondrocytes (ACs) are resistant. As progenitors of all adult tissues, induced pluripotent stem cells (iPSCs) are in theory able to form stable articular cartilage. In vitro...

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Bibliographic Details
Main Authors: Solvig Diederichs, Felicia A. M. Klampfleuthner, Babak Moradi, Wiltrud Richter
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
induced pluripotent stem cells
chondrogenesis
cartilage
hypertrophy
endochondral bone formation
Indian hedgehog
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00270/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2019.00270/full

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