T cell repertoire to citrullinated self-peptides in healthy humans is not confined to the HLA-DR SE alleles; Targeting of citrullinated self-peptides presented by HLA-DP4 for tumour therapy

T cell repertoire to citrullinated self-peptides in healthy humans is not confined to the HLA-DR SE alleles; Targeting of citrullinated self-peptides presented by HLA-DP4 for tumour therapy

Post-translational modifications are induced in stressed cells which cause them to be recognised by the system. One such modification is citrullination where the positive charged arginine is modified to a neutral citrulline. We demonstrate most healthy donors show an oligoclonal CD4 response in vitr...

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Bibliographic Details
Main Authors: Victoria A Brentville, Peter Symonds, Katherine W Cook, Ian Daniels, Tracy Pitt, Mohamed Gijon, Poonam Vaghela, Wei Xue, Sabaria Shah, Rachael L Metheringham, Lindy G Durrant
Format: Article
Language:English
Published: Taylor & Francis Group 2019-05-01
Series:OncoImmunology
Subjects:
citrullination
cancer
hla-dp
cd4 t cells
tumour immunotherapy
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1576490

Internet

http://dx.doi.org/10.1080/2162402X.2019.1576490

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