FAK displacement from focal adhesions: a promising strategy to target processes implicated in cancer progression and metastasis

FAK displacement from focal adhesions: a promising strategy to target processes implicated in cancer progression and metastasis

Abstract Background Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that is overexpressed or activated in several advanced-stage solid cancers. It is known to play both kinase-dependent and -independent roles in promoting tumor progression and metastasis. Numerous inhibitors, targeting...

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Bibliographic Details
Main Authors: Ioanna Antoniades, Maria Kyriakou, Anna Charalambous, Katerina Kalalidou, Andri Christodoulou, Maria Christoforou, Paris A. Skourides
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Cell Communication and Signaling
Subjects:
Focal adhesion kinase (FAK)
Paxillin
Focal adhesions
Cell migration
Cell invasion
Cancer
Online Access:https://doi.org/10.1186/s12964-020-00671-1

Internet

https://doi.org/10.1186/s12964-020-00671-1

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