Complement Factor H and Apolipoprotein E Participate in Regulation of Inflammation in THP-1 Macrophages

Complement Factor H and Apolipoprotein E Participate in Regulation of Inflammation in THP-1 Macrophages

The alternative pathway (AP) of complement is constantly active in plasma and can easily be activated on self surfaces and trigger local inflammation. Host cells are protected from AP attack by Factor H (FH), the main AP regulator in plasma. Although complement is known to play a role in atheroscler...

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Bibliographic Details
Main Authors: Eija Nissilä, Pipsa Hakala, Katarzyna Leskinen, Angela Roig, Shahan Syed, Kok P. M. Van Kessel, Jari Metso, Carla J. C. De Haas, Päivi Saavalainen, Seppo Meri, Angeliki Chroni, Jos A. G. Van Strijp, Katariina Öörni, Matti Jauhiainen, T. Sakari Jokiranta, Karita Haapasalo
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
complement
complement system
Factor H
apolipoprotein E
atherosclerosis
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02701/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02701/full

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