The Role of IGF/IGF-1R Signaling in Hepatocellular Carcinomas: Stemness-Related Properties and Drug Resistance

The Role of IGF/IGF-1R Signaling in Hepatocellular Carcinomas: Stemness-Related Properties and Drug Resistance

Insulin-like Growth Factor (IGF)/IGF-1 Receptor (IGF-1R) signaling is known to regulate stem cell pluripotency and differentiation to trigger cell proliferation, organ development, and tissue regeneration during embryonic development. Unbalanced IGF/IGF-1R signaling can promote cancer cell prolifera...

Full description

Bibliographic Details
Main Authors: Mai-Huong Thi Ngo, Han-Yin Jeng, Yung-Che Kuo, Josephine Diony Nanda, Ageng Brahmadhi, Thai-Yen Ling, Te-Sheng Chang, Yen-Hua Huang
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
insulin-like growth factor
liver cancer
cancer stemness
IGFs inhibitor
targeting drug resistance
Online Access:https://www.mdpi.com/1422-0067/22/4/1931

Internet

https://www.mdpi.com/1422-0067/22/4/1931

Similar Items