Monosodium urate crystals reduce osteocyte viability and indirectly promote a shift in osteocyte function towards a proinflammatory and proresorptive state

Monosodium urate crystals reduce osteocyte viability and indirectly promote a shift in osteocyte function towards a proinflammatory and proresorptive state

Abstract Background Bone erosion is a frequent complication of gout and is strongly associated with tophi, which are lesions comprising inflammatory cells surrounding collections of monosodium urate (MSU) crystals. Osteocytes are important cellular mediators of bone remodeling. The aim of this study...

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Bibliographic Details
Main Authors: Ashika Chhana, Bregina Pool, Karen E. Callon, Mei Lin Tay, David Musson, Dorit Naot, Geraldine McCarthy, Susan McGlashan, Jillian Cornish, Nicola Dalbeth
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Arthritis Research & Therapy
Subjects:
Gout
Osteocyte
Inflammation
Urate
Bone erosion
Online Access:http://link.springer.com/article/10.1186/s13075-018-1704-y

Internet

http://link.springer.com/article/10.1186/s13075-018-1704-y

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