Dysregulation of epithelial ion transport and neurochemical changes in the colon of a parkinsonian primate

Abstract The pathological changes underlying gastrointestinal (GI) dysfunction in Parkinson’s disease (PD) are poorly understood and the symptoms remain inadequately treated. In this study we compared the functional and neurochemical changes in the enteric nervous system in the colon of adult, L-DOP...

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Bibliographic Details
Main Authors: Erika Coletto, Iain R. Tough, Sara Pritchard, Atsuko Hikima, Michael J. Jackson, Peter Jenner, K. Ray Chaudhuri, Helen M. Cox, Mahmoud M. Iravani, Sarah Rose
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-020-00150-x