Development of novel Zn2+ loaded nanoparticles designed for cell-type targeted drug release in CNS neurons: in vitro evidences.

Intact synaptic function and plasticity are fundamental prerequisites to a healthy brain. Therefore, synaptic proteins are one of the major targets for drugs used as neuro-chemical therapeutics. Unfortunately, the majority of drugs is not able to cross the blood-brain barrier (BBB) and is therefore...

Full description

Bibliographic Details
Main Authors: Andreas M Grabrucker, Craig C Garner, Tobias M Boeckers, Lucia Bondioli, Barbara Ruozi, Flavio Forni, Maria Angela Vandelli, Giovanni Tosi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3063171?pdf=render