Urea-Peptide Hybrids as VEGF-A<sub>165</sub>/NRP-1 Complex Inhibitors with Improved Receptor Affinity and Biological Properties

Urea-Peptide Hybrids as VEGF-A<sub>165</sub>/NRP-1 Complex Inhibitors with Improved Receptor Affinity and Biological Properties

Neuropilin-1 (NRP-1), the major co-receptor of vascular endothelial growth factor receptor-2 (VEGFR-2), may also independently act with VEGF-A<sub>165</sub> to stimulate tumour growth and metastasis. Therefore, there is great interest in compounds that can block VEGF-A165/NRP-1 interacti...

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Bibliographic Details
Main Authors: Anna K. Puszko, Piotr Sosnowski, Rachel Rignault-Bricard, Olivier Hermine, Gérard Hopfgartner, Karolina Pułka-Ziach, Yves Lepelletier, Aleksandra Misicka
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
peptidomimetics
amide bond mimetic
neuropilin-1
VEGF-A<sub>165</sub>
protein–ligand interaction
Online Access:https://www.mdpi.com/1422-0067/22/1/72

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https://www.mdpi.com/1422-0067/22/1/72

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