Hsp22 with an N-Terminal Domain Truncation Mediates a Reduction in Tau Protein Levels

Hsp22 with an N-Terminal Domain Truncation Mediates a Reduction in Tau Protein Levels

Misfolding, aggregation and accumulation of proteins are toxic elements in the progression of a broad range of neurodegenerative diseases. Molecular chaperones enable a cellular defense by reducing or compartmentalizing these insults. Small heat shock proteins (sHsps) engage proteins early in the pr...

Full description

Bibliographic Details
Main Authors: Jack M. Webster, April L. Darling, Taylor A. Sanders, Danielle M. Blazier, Yamile Vidal-Aguiar, David Beaulieu-Abdelahad, Drew G. Plemmons, Shannon E. Hill, Vladimir N. Uversky, Paula C. Bickford, Chad A. Dickey, Laura J. Blair
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
small heat shock protein 22
tau
molecular chaperones
neurodegeneration
Alzheimer’s disease
Online Access:https://www.mdpi.com/1422-0067/21/15/5442

Internet

https://www.mdpi.com/1422-0067/21/15/5442

Similar Items