Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR

Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR

The Neurotransmitter:Sodium Symporters (NSSs) represent an important class of proteins mediating sodium-dependent uptake of neurotransmitters from the extracellular space. The substrate binding stoichiometry of the bacterial NSS protein, LeuT, and thus the principal transport mechanism, has been hea...

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Bibliographic Details
Main Authors: Simon Erlendsson, Kamil Gotfryd, Flemming Hofmann Larsen, Jonas Sigurd Mortensen, Michel-Andreas Geiger, Barth-Jan van Rossum, Hartmut Oschkinat, Ulrik Gether, Kaare Teilum, Claus J Loland
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-01-01
Series:eLife
Subjects:
aquifex aeolicus
substrate binding site
neurotransmitter transporters
solid state NMR
LeuT
Online Access:https://elifesciences.org/articles/19314

Internet

https://elifesciences.org/articles/19314

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