Genotypic and functional impact of HIV-1 adaptation to its host population during the North American epidemic.
HLA-restricted immune escape mutations that persist following HIV transmission could gradually spread through the viral population, thereby compromising host antiviral immunity as the epidemic progresses. To assess the extent and phenotypic impact of this phenomenon in an immunogenetically diverse p...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-04-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC3998893?pdf=render |