Positron emission tomography imaging with 89Zr-labeled anti-CD8 cys-diabody reveals CD8+ cell infiltration during oncolytic virus therapy in a glioma murine model

Positron emission tomography imaging with 89Zr-labeled anti-CD8 cys-diabody reveals CD8+ cell infiltration during oncolytic virus therapy in a glioma murine model

Abstract Determination of treatment response to immunotherapy in glioblastoma multiforme (GBM) is a process which can take months. Detection of CD8+ T cell recruitment to the tumor with a noninvasive imaging modality such as positron emission tomography (PET) may allow for tumor characterization and...

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Bibliographic Details
Main Authors: Benjamin B. Kasten, Hailey A. Houson, Jennifer M. Coleman, Jianmei W. Leavenworth, James M. Markert, Anna M. Wu, Felix Salazar, Richard Tavaré, Adriana V. F. Massicano, G. Yancey Gillespie, Suzanne E. Lapi, Jason M. Warram, Anna G. Sorace
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-94887-x

Internet

https://doi.org/10.1038/s41598-021-94887-x

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