Experimental crescentic glomerulonephritis: a new bicongenic rat model

SUMMARY Crescentic glomerulonephritis (CRGN) is a major cause of human kidney failure, but the underlying mechanisms are not fully understood. Wistar Kyoto (WKY) rats are uniquely susceptible to CRGN following injection of nephrotoxic serum, whereas Lewis (LEW) rats are resistant. Our previous genet...

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Bibliographic Details
Main Authors: Zelpha D’Souza, Stephen P. McAdoo, Jennifer Smith, Charles D. Pusey, H. Terence Cook, Jacques Behmoaras, Timothy J. Aitman
Format: Article
Language:English
Published: The Company of Biologists 2013-11-01
Series:Disease Models & Mechanisms
Online Access:http://dmm.biologists.org/content/6/6/1477