The Emerging Role of DNA Damage in the Pathogenesis of the C9orf72 Repeat Expansion in Amyotrophic Lateral Sclerosis

The Emerging Role of DNA Damage in the Pathogenesis of the C9orf72 Repeat Expansion in Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal, rapidly progressing neurodegenerative disease affecting motor neurons, and frontotemporal dementia (FTD) is a behavioural disorder resulting in early-onset dementia. Hexanucleotide (G4C2) repeat expansions in the gene encoding chromosome 9 open reading...

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Bibliographic Details
Main Authors: Anna Konopka, Julie D Atkin
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:International Journal of Molecular Sciences
Subjects:
C9orf72
ALS
motor neuron disease
R loops, nucleolar stress
neurodegeneration
Online Access:http://www.mdpi.com/1422-0067/19/10/3137

Internet

http://www.mdpi.com/1422-0067/19/10/3137

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