Anti-inflammatory Mechanism of Geniposide: Inhibiting the Hyperpermeability of Fibroblast-Like Synoviocytes via the RhoA/p38MAPK/NF-κB/F-Actin Signal Pathway

Geniposide (GE) is the extraction and purification of iridoid glycosides from the Gardenia jasminoides Ellis, which is a promising anti-inflammatory drug, but its mechanism of actions on rheumatoid arthritis (RA) has not been clarified. This study investigated the molecular mechanism behind GE reduc...

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Bibliographic Details
Main Authors: Ran Deng, Feng Li, Hong Wu, Wen-yu Wang, Li Dai, Zheng-rong Zhang, Jun Fu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Pharmacology
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00105/full