SR-BI mediates neutral lipid sorting from LDL to lipid droplets and facilitates their formation.

SR-BI mediates neutral lipid sorting from LDL to lipid droplets and facilitates their formation.

SR-BI binds various lipoproteins, including HDL, LDL as well as VLDL, and mediates selective cholesteryl ester (CE) uptake. HDL derived CE accumulates in cellular lipid droplets (LDs), which also store triacylglycerol (TAG). We hypothesized that SR-BI could significantly facilitate LD formation, in...

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Bibliographic Details
Main Authors: Tatyana G Vishnyakova, Alexander V Bocharov, Irina N Baranova, Roger Kurlander, Steven K Drake, Zhigang Chen, Marcelo Amar, Denis Sviridov, Boris Vaisman, Eugenia Poliakov, Alan T Remaley, Thomas L Eggerman, Amy P Patterson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0240659

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https://doi.org/10.1371/journal.pone.0240659

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