Unbiased Profiling Reveals Compartmentalization of Unconventional T-Cells Within the Intestinal Mucosa Irrespective of HIV Infection

Unbiased Profiling Reveals Compartmentalization of Unconventional T-Cells Within the Intestinal Mucosa Irrespective of HIV Infection

The intestinal mucosa is enriched for unconventional T-cells, including mucosal associated invariant T-cells (MAIT), invariant natural killer T-cells (iNKT) and γδ T-cells. These cells are activated by bacterial metabolites, lipid antigens and cytokines, and are important for intestinal barrier inte...

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Bibliographic Details
Main Authors: Magalli Magnoumba, Alveera Singh, Paul Ogongo, Julia Roider, Osaretin Asowata, Michael Fehlings, Farina Karim, Thumbi Ndung'u, Frank Anderson, Alasdair Leslie, Henrik Kløverpris
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
unconventional T-cells
MAIT cells
iNKT cells
intestinal mucosa
HIV infection
TCR repertoire
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.579743/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.579743/full

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