The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition)

The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition)

Abstract Aims The accumulation of advanced glycation end products is implicated in the development and progression of diabetic kidney disease. No study has examined whether stimulating advanced glycation clearance via receptor manipulation is reno‐protective in diabetes. Podocytes, which are early c...

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Bibliographic Details
Main Authors: Aowen Zhuang, Felicia Y. T. Yap, Danielle J. Borg, Domenica McCarthy, Amelia Fotheringham, Sherman Leung, Sally A. Penfold, Karly C. Sourris, Melinda T. Coughlan, Benjamin L. Schulz, Josephine M. Forbes
Format: Article
Language:English
Published: Wiley 2021-07-01
Series:Endocrinology, Diabetes & Metabolism
Subjects:
advanced glycation end‐product receptor 1
advanced glycation end‐products
diabetes
diabetic kidney disease
endoplasmic reticulum stress
oligosaccharyltransferase‐48 diabetic nephropathy
Online Access:https://doi.org/10.1002/edm2.278

Internet

https://doi.org/10.1002/edm2.278

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