Sample size calculations based on a difference in medians for positively skewed outcomes in health care studies

Sample size calculations based on a difference in medians for positively skewed outcomes in health care studies

Abstract Background In healthcare research, outcomes with skewed probability distributions are common. Sample size calculations for such outcomes are typically based on estimates on a transformed scale (e.g. log) which may sometimes be difficult to obtain. In contrast, estimates of median and varian...

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Bibliographic Details
Main Authors: Aidan G. O’Keeffe, Gareth Ambler, Julie A. Barber
Format: Article
Language:English
Published: BMC 2017-12-01
Series:BMC Medical Research Methodology
Subjects:
Hypothesis test
Log-transformation
Median
Sample size
Skewness
Online Access:http://link.springer.com/article/10.1186/s12874-017-0426-1

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http://link.springer.com/article/10.1186/s12874-017-0426-1

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