Recombinant Adeno Associated Viral (AAV) vector type 9 delivery of Ex1-Q138-mutant huntingtin in the rat striatum as a short-time model for in vivo studies in drug discovery

Recombinant Adeno Associated Viral (AAV) vector type 9 delivery of Ex1-Q138-mutant huntingtin in the rat striatum as a short-time model for in vivo studies in drug discovery

Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by dyskinesia, cognitive impairment and emotional disturbances, presenting progressive neurodegeneration in the striatum and intracellular mutant Huntingtin (mHTT) aggregates in various areas of the brain. Recomb...

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Bibliographic Details
Main Authors: Ilaria Ceccarelli, Pasquale Fiengo, Rosaria Remelli, Vincenzo Miragliotta, Lara Rossini, Irene Biotti, Alessandra Cappelli, Lara Petricca, Salvatore La Rosa, Andrea Caricasole, Giuseppe Pollio, Carla Scali
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Neurobiology of Disease
Subjects:
Huntington's disease
Viral vectors
Neurodegeneration
Neuroinflammation immunohistochemistry
Animal model
In vivo spectroscopy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115300978

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http://www.sciencedirect.com/science/article/pii/S0969996115300978

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