Evolutionary constraint and disease associations of post-translational modification sites in human genomes.
Interpreting the impact of human genome variation on phenotype is challenging. The functional effect of protein-coding variants is often predicted using sequence conservation and population frequency data, however other factors are likely relevant. We hypothesized that variants in protein post-trans...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
|
Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC4303425?pdf=render |