Soluble glycoprotein VI, a specific marker of platelet activation is increased in the plasma of subjects with seropositive rheumatoid arthritis.

Soluble glycoprotein VI, a specific marker of platelet activation is increased in the plasma of subjects with seropositive rheumatoid arthritis.

Anti-citrullinated protein antibodies (ACPA) have been shown to cause platelet activation in vitro, through the low-affinity immunoglobulin G (IgG) receptor (FcγRIIa) on platelets. Platelet activation via engagement of FcγRIIa results in proteolytic cleavage and shedding of platelet specific glycopr...

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Bibliographic Details
Main Authors: John R Stack, Anne Madigan, Laura Helbert, Eimear Dunne, Elizabeth E Gardiner, Robert K Andrews, Roisin Finan, Elizabeth Smyth, Dermot Kenny, Geraldine M McCarthy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5687752?pdf=render

Internet

http://europepmc.org/articles/PMC5687752?pdf=render

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