Soluble glycoprotein VI, a specific marker of platelet activation is increased in the plasma of subjects with seropositive rheumatoid arthritis.
Anti-citrullinated protein antibodies (ACPA) have been shown to cause platelet activation in vitro, through the low-affinity immunoglobulin G (IgG) receptor (FcγRIIa) on platelets. Platelet activation via engagement of FcγRIIa results in proteolytic cleavage and shedding of platelet specific glycopr...
Main Authors: | John R Stack, Anne Madigan, Laura Helbert, Eimear Dunne, Elizabeth E Gardiner, Robert K Andrews, Roisin Finan, Elizabeth Smyth, Dermot Kenny, Geraldine M McCarthy |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC5687752?pdf=render |
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